Scientists find key to obesity
Scientists find key to obesity (Thinkstock/AP)
Scientists find key to obesity
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Scientists have finally figured out how the key gene tied to obesity makes people fat. It is a major discovery that could open the door to an entirely new approach to the problem beyond diet and exercise.
The work solves a big mystery. Since 2007, researchers have known that a gene called FTO was related to obesity. But they didn't know how, and could not tie it to appetite or other known factors.
Now experiments reveal that a faulty version of the gene causes energy from food to be stored as fat rather than burned. Genetic tinkering in mice and on human cells in the lab suggests this can be reversed, giving hope that a drug or other treatment might be developed to do the same in people.
The work was led by scientists at MIT and Harvard University. The results were published online by the New England Journal of Medicine.
The discovery challenges the notion that "when people get obese it was basically their own choice because they choose to eat too much or not exercise," said study leader Melina Claussnitzer. She is a genetics specialist at Harvard-affiliated Beth Israel Deaconess Medical Center. "For the first time, genetics has revealed a mechanism in obesity that was not really suspected before" and gives a third explanation or factor that's involved.
Independent experts praised the discovery.
"It's a big deal," said Dr. Clifford Rosen. He is a scientist at Maine Medical Center Research Institute. He also is an associate editor at the medical journal.
"A lot of people think the obesity epidemic is all about eating too much," but our fat cells play a role in how food gets used, he said. With this discovery, "you now have a pathway for drugs that can make those fat cells work differently."
Several obesity drugs are already on the market. They are generally used for short-term weight loss and are aimed at the brain and appetite. They don't directly target metabolism.
Researchers can't guess how long it might take before a drug based on the new findings becomes available. But it's unlikely it would be a magic pill that would enable people to eat anything they want without packing on the pounds. And targeting this fat pathway could affect other things, so a treatment would need rigorous testing to prove safe and effective.
The gene glitch doesn't explain all obesity. It was found in 44 percent of Europeans but only 5 percent of blacks, so other genes clearly are at work, and food and exercise still matter.
Having the glitch doesn't destine you to become obese. But it may predispose you to it. People with two faulty copies of the gene (one from Mom and one from Dad) weighed an average of 7 pounds more than those without them. But some were obviously a lot heavier than that. And even 7 pounds can be the difference between a healthy and an unhealthy weight, said Manolis Kellis. He is a professor at MIT.
He and Claussnitzer are seeking a patent related to the work. It was done on people in Europe, Sweden and Norway. The research was funded by the German Research Center for Environmental Health and others, including the U.S. National Institutes of Health.
Obesity affects more than 500 million people worldwide and contributes to a host of diseases. In the U.S., about one-third of adults are obese. Another one-third are more modestly overweight.

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Armed with this new knowledge, what are the next steps to finding possible cures?
Write your answers in the comments section below

  • jacobw-2-bro
    8/27/2015 - 02:07 p.m.

    kinda cool and scary : )

  • afrikab-ric
    8/31/2015 - 11:27 a.m.

    I'm african american,and I'm skinny. I don't know how much I weigh, but on the outside I look skinny. So I don't see how black females get the highest obesity rate honestly.

  • masonp-mar
    9/11/2015 - 10:21 a.m.

    Truly astonishing, now people can't say to obese people "how many chocolate did you eat today." Now we know it can be about genetics, not just food or exercise!

  • ethanw-fel
    9/11/2015 - 02:17 p.m.

    The next steps are that we now have a pathway for drugs that can make those fat cells work differently.

  • kyleighp-fel
    9/11/2015 - 02:20 p.m.

    The next step to finding possible cures is rigorous testing and retesting to make sure the cure is safe for human usage.

  • kolbyd-fel
    9/11/2015 - 02:21 p.m.

    The next step is finding out how to reverse the gene.

  • coled-fel
    9/11/2015 - 02:21 p.m.

    CTQ: The next steps could be to test the new knowledge. Make sure that the new knowledge works and will be defined as working, before making some kind of product with it.

  • garretta-fel
    9/11/2015 - 02:22 p.m.

    The next steps in finding a cure are to study more about how this "metabolism theory" works in effect to how we store fat.

  • elizabetht-fel
    9/11/2015 - 02:23 p.m.

    This new knowledge shows that a cure could be found through different means of treatments and medications. They could create a treatment that could target that gene and that gene alone. It would only target the obesity gene and cure it that way.

  • mattv-fel
    9/11/2015 - 02:23 p.m.

    Doctors or scientists could possibly attempt to destroy the gene or find a way to correct the gene, since obesity is caused by a faulty version of the gene.

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